吴明

预防保健与医院感染管理部

主任

硕士生导师、博士后合作导师

PI介绍

       365游戏大厅(深圳市转化医学研究院)预防保健与医院感染管理部主任,医学博士,硕士研究生导师、博士后合作导师。主要从事脓毒症、严重创伤、ARDS、AKI、SAP、MODS等的临床救治20余年,熟练掌握了重症超声、纤维支气管镜肺泡灌洗、血浆净化及ECMO等技术。擅长危重病救治及多重耐药菌感染的综合防治。在脓毒症、重症凝血、AKI、CRRT、MODS基础及临床研究方面有较深的理解。

      现任中国康复医学会重症康复专业委员会生命支持学组常委、中国研究型医院学会血栓与止血分会委员、中国医药教育协会血栓与止血危重病专业委员会委员、广东省临床医学学会血浆治疗专业委员会常委、广东省病理生理学会危重病专业委员会委员、深圳市医学会重症医学专业委员会副主任委员、深圳市健康管理学会血液净化专业委员会副主任委员等。现为深圳大学、汕头大学医学院、广东医科大学、广西中医药大学等高校硕士研究生导师,已招收全日制硕士研究生5人;近5年来主持省、市院级基金6项,发表学术论文50余篇,其中以第一或通讯作者发表SCI文章20篇,申请国家发明专利2项、实用新型专利2项,获得国家发明专利及实用新型专利各1项,现为European Journal of Internal Medicine、Kidney and Blood Pressure Research、Platelets、Renal Failure、frontiers in medicine等杂志审稿人。

科研项目

1.  深圳市科技创新委员会,面上项目,JCYJ20190806163603504,Caveolin-1调控内质网应激影响肾小管铁死亡在重症中暑肾损伤中的机制研究,2020-08至2023-07,10万元,在研,主持;

2. 深圳市科技创新委员会,面上项目,JCYJ20170306091335008,黄芩素调控巨噬细胞线粒体自噬对脓毒症小鼠肾小管焦亡影响的实验研究,2017-05至2020-05,25万元,已结题,主持;

3. 广东省高水平医院建设--365游戏大厅,临床研究项目,20193357003,肾血流阻力指数在预测脓毒症急性肾损伤价值的临床研究,2019-07至2022-06,30万元,在研,主持;

4. 广东省高水平医院建设--365游戏大厅,临床研究项目,20203357014,黄连素治疗脓毒症合并急性胃肠损失的单中心随机双盲对照试验,2020-07至2023-06,15万元,在研,主持;

5. 深圳市卫生健康委,临床研究项目,SZLY2017007,连续血液滤过吸附联合血浆置换治疗脓毒症合并MODS的RCT研究,2017-06至2020-05,30万元,结题,主持。

代表性成果

1)Yingyi Luan; Yan Liu; Xueyan Liu; Bao-jun Yu; Rong-ling Chen; Mian Peng; Di Ren; Hao-li Li; Lei Huang; Yong Liu; Jin-xiu Li; Yong-wen Feng; Ming Wu. Coronavirus disease 2019 (COVID-19) associated coagulopathy and its impact on outcomes in Shenzhen, China: A retrospective cohort study. Thrombosis Research, 2020, 195: 62-68.

2)Ziyun Shao, Yongwen Feng, Li Zhong, Qifeng Xie, Ming Lei; Zheying Liu; Conglin Wang, Jingjing Ji; Huiheng Liu, Zhengtao Gu; Zhongwei Hu, Lei Su, Ming Wu, Zhifeng Liu. Clinical efficacy of intravenous immunoglobulin therapy in critical ill patients with COVID-19: a multicenter retrospective cohort study. Clinical & Translational Immunology, 2020, 9(e1192)

3)Ming Wu, Jing-jing Ji, Li Zhong, Zi-yun Shao, Qi-feng Xie, Zhe-ying Liu, Cong-lin Wang, Lei Su, Yong-wen Feng, Zhi-feng Liu, Yong-ming Yao. Thymosin a1 Therapy in Critically Ill Patients with COVID-19: a Multicenter Retrospective Cohort Study. International Immunopharmacology,2020(88)106873.

4)Jingjing Ji, Ming Wu, Li Zhong, Zheying Liu, Conglin Wan, Ziyun Shao, Qifeng Xie, Zhifeng Liu. Early, low-dose, short-term methylprednisolone decreased the mortality in critical COVID-19 patients: A multicenter retrospective cohort study. J Infect, 2021, 82(4):84-123.

5)Ying-yi Luan, Yan-Hong Chen, Xue Li, Zhi-Peng Zhou, Jia-Jia Huang, Zhen-Jia Yang, Jing-Jing Zhang, Ming Wu. Clinical characteristics and risk factors for critically ill patients with carbapenem-resistant Klebsiella pneumonia (CrKP): A cohort study from developing country. Infection and Drug Resistance,2021,14:5555-5562.

6)Ming Wu, Conglin Wang, Li Zhong, Zhifeng Liu. Serum myoglobin as predictor of acute kidney injury and 90-day mortality in patients with rhabdomyolysis after exertional heatstroke: an over 10-year intensive care survey, Int J Hyperthermia. 2022;39(1):446-454.

7)Ming Wu, Conglin Wang, Zheying Liu, Zhifeng Liu. Sequential Organ Failure Assessment score for Prediction of Mortality of Patients with Rhabdomyolysis Following Exertional Heatstroke:A Longitudinal Cohort Study in Southern China. Front Med, 2021, 9: 724319.

8)Ming Wu, Conglin Wang, Zheying Liu, Li Zhong, Baojun Yu, Biao Cheng, Zhifeng Liu. Clinical characteristics and risk factors associated with acute kidney injury inpatient with exertional heatstroke: an over 10-year intensive care survey. Front Med, 2021, 8: 678434.

9)Ming Wu, Ying-Yi Luan, Jun-Fu Lu, Haoli Li, Hai-Chao Zhan, Yan-Hong Chen, Fan Zhang, Yu-Yu Tian, Zi-Long Yang, Yong-Ming Yao, Yong-Wen Feng. Platelet Count as a New Biomarker for Acute Kidney Injury Induced by Haemorrhagic Shock. Platelets, 2020, 31, 1: 94-102.

10)Li Zhong, Ming Wu, Jingjing Ji, Conglin Wang, Zhifeng Liu. Association Between Platelet Levels on Admission and 90-day Mortality in Patients with Exertional Heatstroke, a 10 Years Cohort Study. Frontiers Med, 2021, 11: 716058.

11)Chuang Yuan, Ming Wu, Qicai Xiao, Wang Zhao, Hongli Li, Yanjun Zhong, Minyi Zhao, Cheng Li, Yang Li, Xinyu Yang. Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis. Signal Transduction and Targeted Therapy, 2021,6(1):92

科研团队

硕士研究生:黄佳佳、周志鹏、杨镇嘉、张晶晶、李达政、于佳敏、杨子龙(毕业)

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